My Favorite Husband began on CBS Radio with Lucille Ball and Richard Denning as Liz and George Cugat. After at least 20 early episodes, confusion with bandleader Xavier Cugat prompted a name change to Liz and George Cooper. The cheerful couple lived at 321 Bundy Drive in the fictitious city of Sheridan Falls and were billed as "two people who live together and like it." The main sponsor was General Foods' Jell-O, and an average of three "plugs" for Jell-O were made in each episode, including Lucille Ball's usual sign-on, "Jell-O, everybody!"
The program, which aired 124 episodes from July 23, 1948, through March 31, 1951, initially portrayed the couple as being a well-to-do banker and his socially prominent wife, but three new writers — Bob Carroll, Jr., Madelyn Pugh, and Jess Oppenheimer — took over the writing, changed the couple's name to Cooper, and remade them into a middle-class couple, which they thought average listeners would find more accessible.
Lucille Ball was asked to do a television version of the show (with Jell-O remaining as sponsor), and CBS insisted on Richard Denning continuing as her co-star. However, Ball refused to do a husband-and-wife TV show without real-life husband Desi Arnaz playing her on-screen husband. The network reluctantly agreed, reworking the concept into I Love Lucy after Ball and Arnaz took a show on the road to convince the network that audiences would respond. When Jell-O dropped out of the show, Philip Morris became the television sponsor.
Carroll, Pugh and Oppenheimer agreed to do the switch to I Love Lucy. They subsequently reworked several My Favorite Husband episodes into I Love Lucy episodes, especially early in the TV show's run. For example, the 1948 radio episode entitled "Giveaway Program" inspired the I Love Lucy episode "Redecorating", with some lines exactly the same. Many actors who had done the My Favorite Husband radio show also appeared on I Love Lucy, sometimes in episodes where they reprised their roles using a reworked My Favorite Husband script.